Interaction of TM6SF2 E167K and PNPLA3 I148M variants in NAFLD in northeast China
نویسندگان
چکیده
منابع مشابه
The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism
There is a genetic susceptibility for nonalcoholic fatty liver disease (NAFLD). To examine the role of genetic factors in the disease, a Bayesian analysis was performed to model gene relationships in NAFLD pathogenesis. The Bayesian analysis indicated a potential gene interaction between the TM6SF2 and PNPLA3 genes. Next, to explore the underlying mechanism at the cellular level, we evaluated t...
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15 صفحه اولBidirectional Relationships and Disconnects between NAFLD and Features of the Metabolic Syndrome.
Non-alcoholic fatty liver disease (NAFLD) represents a wide spectrum of liver disease from simple steatosis, to steatohepatitis, (both with and without liver fibrosis), cirrhosis and end-stage liver failure. NAFLD also increases the risk of hepatocellular carcinoma (HCC) and both HCC and end stage liver disease may markedly increase risk of liver-related mortality. NAFLD is increasing in preval...
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ژورنال
عنوان ژورنال: Annals of Hepatology
سال: 2019
ISSN: 1665-2681
DOI: 10.1016/j.aohep.2018.10.005